A molecular wound response program associated with regeneration initiation in planarians
نویسندگان
چکیده
منابع مشابه
A regulatory program for excretory system regeneration in planarians.
Planarians can regenerate any missing body part, requiring mechanisms for the production of organ systems in the adult, including their prominent tubule-based filtration excretory system called protonephridia. Here, we identify a set of genes, Six1/2-2, POU2/3, hunchback, Eya and Sall, that encode transcription regulatory proteins that are required for planarian protonephridia regeneration. Dur...
متن کاملRegeneration and pattern formation in planarians
In planarians, blastema cells do not divide, and growth of blastema is thought to result from the steady accumulation, beneath the wound epithelium, of undifferentiated cells produced by cell division in the stump. However, whether these cells come only from local stump sources or whether cells placed far from the wound can also participate, after long-range migrations, in the growth of blastem...
متن کاملiTRAQ-Based Quantitative Proteomic Analysis of the Initiation of Head Regeneration in Planarians
The planarian Dugesia japonica has amazing ability to regenerate a head from the anterior ends of the amputated stump with maintenance of the original anterior-posterior polarity. Although planarians present an attractive system for molecular investigation of regeneration and research has focused on clarifying the molecular mechanism of regeneration initiation in planarians at transcriptional l...
متن کاملRegeneration: Organizing the Blastema in Planarians
The processes that trigger regeneration after injury and link new and old tissue are not fully understood. New findings indicate that, after decapitation, planarians build an organizing center from stem cells at the old midline that directs head patterning and outgrowth.
متن کاملStem cells and regeneration in planarians.
Understanding stem cells is a major goal of current research because of its potential medical applications. Although great advances have been made, such as the culturing and differentiation of embryonic stem cells and reprogramming of cell fates, many basic questions remain unanswered. Describing the mechanisms underlying regeneration will help to understand the biology of stem cells and theref...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2012
ISSN: 0890-9369
DOI: 10.1101/gad.187377.112